What results in osteoporosis?

The development of osteoporosis is primarily linked to a decrease in the activity of osteoblasts, which are the cells responsible for bone formation. When osteoblast activity declines, the bone remodeling process is disrupted, leading to a net loss of bone mass. Osteoclasts, the cells that break down bone, continue to function at normal levels in this scenario. As a result, when the rate of bone resorption by osteoclasts exceeds the rate of new bone formation by osteoblasts, it leads to an overall reduction in bone density and strength, characteristic of osteoporosis.

In contrast, excessive calcium absorption in bones does not directly cause osteoporosis; instead, it could lead to other bone-related issues. Increased production of collagen could support bone strength rather than contribute to osteoporosis. Finally, a reduction in osteoclast activity would actually help preserve bone mass rather than leading to osteoporosis. This context highlights the importance of balanced activity between osteoblasts and osteoclasts in maintaining healthy bone density.