What type of mutation is indicated by the change from original sequence 123456 to mutated sequence 154326?

The change from the original sequence 123456 to the mutated sequence 154326 is indicative of an inversion. In genetics, an inversion occurs when a segment of a chromosome is reversed end to end.

In this case, the original sequence presented as a linear order is altered such that the relative order of the numbers is rearranged while maintaining all original numbers. The sequence has parts of the order inverted: the original '234' is now seen as '432' in the new sequence, demonstrating that these numbers have been flipped around their original position. The remaining numbers '1', '5', and '6' remain in their relative positions before and after the mutation, which is consistent with the definition of an inversion.

In contrast, other types of mutations such as deletion would mean a part of the sequence is missing, duplication would involve the repetition of a segment, and substitution would involve the replacement of one base or number with another. In this scenario, none of those other mutations accurately describes the described change.